師資隊伍

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師資介紹

姓名:劉貽堯

職位:生物技術系正高-教授、博導

聯系方式:liuyiyao@uestc.edu.cn

個人背景 研究方向 科研項目 論文列表 教學工作 其他信息
1994/09-1998/07 重慶大學材料科學與工程學院,材料工程游戏真人平台,學士
1998/09-2001/07 重慶大學生物工程學院,生物醫學工程,碩士
2001/09-2004/09 日本群馬大學生物化學工程系游戏真人平台,生物物理,博士
2004/09-2008/07 電子科技大學生命科學與技術學院,副教授
2005/12-2007/09 日本德島大學醫學部游戏真人平台,博士后
2009/12-2017/12 電子科技大學生命科學與技術學院,副院長
2014/07-2014/08 德國卡爾斯魯厄理工學院(KIT),訪問教授
2008/07-至今  電子科技大學生命科學與技術學院游戏真人平台,教授/博士生導師
1.腫瘤細胞力學與細胞信號轉導
2.腫瘤微納醫學工程與分子成像

近年主持的主要科研項目: 1. 三維胞外基質粘彈性影響乳腺癌細胞凋亡和自噬交互作用的力學生物學機制研究,國家自然科學基金(no. 11772088) 2. 腫瘤微環境基質理化特性對腫瘤起始細胞上皮-間質轉換調控的生物力學機制研究,四川省科技廳應用基礎研究項目(no. 2017JY0019) 3. 小窩蛋白-1在腫瘤細胞抗失巢凋亡力學信號轉導中的功能與調控機制研究,國家自然科學基金(no. 31470906) 4. 基因與化療藥物共輸送的PLGA超聲納米泡的構建及其協同抗腫瘤作用與超聲成像規律研究,四川省杰出青年基金(2014JQ0008) 5. 剪切力調控腫瘤細胞粘附與遷移新機制:整合素alpha(v)beta(3)和GP IIb/IIIa作用規律及其力學生物學機制研究,國家自然科學基金(no. 11272083) 6. 生物-磁雙重靶向Fe3O4@SiO2納米熒光探針制備及其生物醫學應用初步研究,國家自然科學基金(no.81071257) 7. 剪切流場下靶向抗-VCAM-1超聲微泡在內皮細胞上的粘附規律及其在動脈粥樣硬化檢測中的應用,國家自然科學基金(no. 30700151) 8. 多功能化熒光納米探針的構建及其在心血管疾病早期診斷中的應用基礎研究,教育部新世紀優秀人才支持計劃(no. NCET-09-0263)



已經發表SCI收錄論文60余篇(*通訊作者)游戏真人平台,主要論文如下:(具體見實驗室網站:http://biophysics.uestc.edu.cn)
01. Li T, Shen X, Xie X, Chen Z, Li S, Qin X, Yang H, Wu C, Liu Y*. (2018) Irinotecan/IR-820 co-loaded hollow mesoporous silica nanoparticles as a platform for combinational chemotherapy and photothermal therapy of tumor. Nanomedicine. (accepted, in press) 
02. Zhang J, Li L, Peng Y, Chen Y, Li S, Qin X, Yang H, Wu C, Liu Y*. (2018) Surface chemistry induces mitochondria-mediated apoptosis of breast cancer cells via PTEN/PI3K/AKT signaling pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1865: 172-185. 
03. Yang H, Zhang C, Li T, Shen X, Chen Z, Xie X, Li S, Qin X, Wu C, Liu Y*. (2017) Rational design of multifunctional polymeric micelles with stimuli-responsive property for imaging-guided combination cancer therapy. Journal of Biomedical Nanotechnology. 13(10): 1221-1234. 
04. Li L, Tang P, Li S, Qin X, Yang H, Wu C, Liu Y*. (2017) Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy. Medical Oncology. 34:180. doi: 10.1007/s12032-017-1039-6. (invited review). 
05. Li S, Lu J, Chen Y, Xiong N, Li L, Zhang J, Yang H, Wu C, Zeng H, Liu Y*. (2017) MCP-1-triggered ERK/GSK-3beta/Snail pathway facilitates epithelial- mesenchymal transition and promotes cell migration of human breast carcinoma MCF-7 cells. Cellular & Molecular Immunology. 14: 621-630. 
06. Shen X, Li T, Chen Z, Geng Y, Xie X, Li S, Yang H, Wu C, Liu Y*. (2017) PLGA-based luminescent/magnetic hybrid nanocomposites: a versatile nanocarrier system for targeted drug/gene delivery and dual-modality imaging in cancer theranostics. International Journal of Nanomedicine. 12: 4299-4322. 
07. Zhang G, Fan N, Lv X, Liu Y, Guo J, Yang L, Peng B*, Jiang H*. (2017) Investigation of the mechanical properties of human osteosarcoma cell at different cell cycle stages. Micromachines. 8(3), 89; DOI: 10.3390/mi8030089. 
08. Yang H, Chen Y, Chen Z, Geng Y, Shen X, Li T, Li S, Wu C, Liu Y*. (2017) Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayers-modified magnetic mesoporous silica nanocomposites. Biomaterials Science. 5: 1001-1013. 
09. Wu C, Li D, Wang L, Guan X, Tian Y, Yang H, Li S, Liu Y*. (2017) Single wavelength light-mediated, synergistic bimodal cancer photoablation and amplified photothermal performance by graphene/gold nanostar/photosensitizer theranostics. Acta Biomaterialia. 53: 631-642. 
10. Xiong N, Li S, Tang K, Bai H, Peng Y, Yang H, Wu C, Liu Y*. (2017). Involvement of caveolin-1 in low shear stress-induced breast cancer cell motility and adhesion: roles of FAK/Src and ROCK/p-MLC pathways. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 1864: 12-22. 
11. Jiang Y, Sverdlov MS, Toth PT, Huang L, Du G, Liu Y, Natarajan V, Minshall RD*. (2016) Phosphatidic acid produced by RalA-activated PLD2 stimulates caveolae-mediated endocytosis and trafficking in endothelial cells. Journal of Biological Chemistry. 291: 20729-20738. 
12. Gao Z, Li T, Xu X, Liu Y, Luo H*, Li N*. (2016) Green light-emitting polyepinephrine-based fluorescent organic dots and its application in intracellular metal ions sensing. Biosensors and Bioelectronics. 83: 134-141. 
13. Li T, Shen X, Geng Y, Chen Z, Li L, Li S, Yang H, Wu C, Zeng H, Liu Y*. (2016) Folate-functionalized magnetic-mesoporous silica nanoparticles for drug/gene co-delivery to potentiate the antitumor efficacy. ACS Applied Materials & Interfaces. 8: 13748-13758. 
14. Yang H, Xu M, Shen X, Li T, Yan J, Zhang C, Wu C, Zeng H, Liu Y*. (2016) Chitosan hybrid nanoparticles as a theranostic platform for targeted doxorubicin/VEGF shRNA co-delivery and dual-modality fluorescence imaging. RSC Advances. 6: 29685-29696. 
15. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y*. (2016) Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. 7(13): 16227-16247. 
16. Li L, Zhang J, Xiong N, Li S, Chen Y, Yang H, Wu C, Zeng H, Liu Y*. (2016) Notch-1 signaling activates NF-?B in human breast carcinoma MDA-MB-231 cells via PP2A-dependent PI3K/AKT pathway. Medical Oncology. 33:33. DOI: 10.1007/s12032-016-0747-7. 
17. Wu M, Li T, Chen L, Peng S, Liao W, Bai R, Zhao X, Yang H, Wu C, Zeng H, Liu Y*. (2016) Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology. 180: 18-27. 
18. Wu C, Zhu A, Li D, Wang L, Yang H, Zeng H, Liu Y*. (2016) Photosensitizer-assembled PEGylated graphene-copper sulfide nanohybrids as a synergistic near-infrared phototherapeutic agent. Expert Opinion on Drug Delivery. 13: 155-165. 
19. Yang H, Deng L, Li T, Shen X, Yan J, Zuo L, Wu C, Liu Y*. (2015) Multifunctional PLGA nanobubbles as theranostic agents: Combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. Journal of Biomedical Nanotechnology. 11: 2124-2136. 
20. Li S, Zhang J, Yang H, Wu C, Dong X, Liu Y*. (2015) Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition. Scientific Reports. 5: 12410; DOI: 10.1038/srep12410. 
21. Zeng H, Agyapong D.A.Y, Li C, Zhao R, Yang H, Wu C, Jiang Y, Liu Y*. (2015) A carcinoembryonic antigen optoelectronic immunosensor based on thiol-derivative-nanogold labeled anti-CEA antibody nanomaterial and gold modified ITO. Sensors & Actuators B: Chemical. 221: 22-27. 
22. Li T, Shen X, Chen Y, Zhang C, Yan J, Yang H, Wu C, Zeng H, Liu Y*. (2015) Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and MR imaging. International Journal of Nanomedicine. 10: 4279-4291.
23. Wu C, He Q, Zhu A, Li D, Xu M, Yang H, Liu Y*. (2014) Synergistic anticancer activity of photo- and chemo-responsive nanoformulation based on polylysine-functionalized graphene. ACS Applied Materials & Interfaces. 6(23): 21615-21623. 
24. Yang H(#), Li Y(#), Li T, Xu M, Chen Y, Wu C, Liu Y*. (2014) Multifunctional core/shell Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports. 4: 7072; DOI: 10.1038/srep07072. 
25. Li L, Zhao F, Lu J, Li T, Yang H, Wu C, Liu Y*. (2014) Notch-1 signaling promotes the malignant features of human breast cancer through NF-kB activation. PLoS ONE. 9(4): e95912. 
26. Zhao F, Li L, Guan L, Yang H, Wu C, Liu Y*. (2014) Roles of GP IIb/IIIa and αvβ3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. Cancer Letters. 344: 62-73.  
27. Deng L, Li L, Yang H, Li L, Zhao F, Wu C, Liu Y*. (2014) Development and optimization of doxorubicin loaded PLGA nanobubbles for drug delivery into HeLa cells. Journal of Nanoscience and Nanotechnology. 14: 2947-2954. 
28. Wu C*, He Q, Zhu A, Yang H, Liu Y*. (2014) Probing the protein conformation and adsorption behaviors in nanographene oxide-protein complexes. Journal of Nanoscience and Nanotechnology. 14: 2591-2598.  
29. Yang H, Shi M, Xu M, Li Y, Wu C, Liu Y*. (2013) Multifunctional silica nanoparticles as theranostic agents: combining VEGF gene delivery and dual-modality cellular imaging. Journal of Controlled Release. 172(1): e120-e121. 
30. Yang H, Zhao F, Li Y, Xu M, Li L, Wu C, Miyoshi H, Liu Y*. (2013) VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro. International Journal of Nanomedicine. 8: 1897-1906. 
31. Liu Y*, Shi M, Xu M, Yang H, Wu C. (2012) Multifunctional nanoparticles of Fe3O4@SiO2(FITC)/PAH conjugated the recombinant plasmid of pIRSE2-EGFP/VEGF165 with dual functions for gene delivery and cellular imaging. Expert Opinion on Drug Delivery. 9(10): 1197-1207. 
32. Yang H, Zhang L, Xiong X, Liu Y*. (2011) Specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation. Journal of Controlled Release. 152(s1): e227-e229. 
33. Shi M, Liu Y*, Xu M, Yang H, Wu C, Miyoshi H. (2011) Core/shell Fe3O4@SiO2 nanoparticles modified with PAH as a vector for EGFP plasmid DNA delivery into HeLa cells. Macromolecular Bioscience. 11: 1563-1569. 
34. Yang H(#), Lou C(#), Xu M, Wu C, Miyoshi H, Liu Y*. (2011) Investigation of folate conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism. International Journal of Nanomedicine. 6: 2023-2032. 
35. Yang H, Xiong X, Zhang L, Wu C, Liu Y*. (2011) Adhesion of bio-functionalized ultrasound microbubbles to endothelial cells by targeting to vascular cell adhesion molecule-1 under shear flow. International Journal of Nanomedicine. 6: 2043-2051. 
36. Liu Y*, Lou C, Yang H, Shi M, Miyoshi H. (2011) Silica nanoparticles as potential drug/gene delivery carriers and fluorescent nano-probes: recent advances. Current Cancer Drug Targets. 11: 156-163.  
37. Xiong X, Zhao F, Shi M, Yang H, Liu Y*. (2011) Polymeric microbubbles for ultrasonic molecular imaging and targeted therapeutics. Journal of Biomaterials Science-Polymer Edition. 22: 417-428. 
38. Meng G, Liu Y*, Lou C, Yang H. (2010) Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-kB activation by disrupting lipid rafts in CD14-negative endothelial cells. British Journal of Pharmacology. 161: 1628-1644. 
39. Yang H, Liu Z, Liu Y*, Lou C, Ren Z, Miyoshi H. (2010) Vascular gene transfer and drug delivery in vitro using low frequency ultrasound and microbubbles. Acta Pharmacologica Sinica. 31: 515-522.
40. Yang H, Miyoshi H, Lou C, Ren Z, Liu Y*. (2010) Preparation, characterization and release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA. Chinese Science Bulletin. 55: 263-267. 
41. Liu Y*, Zhao F, Gu W, Yang HS, Meng Q,  Zhang Y, Yang H, Duan Q. (2009) The Roles of Platelet GPIIb/IIIa and αvβ3 integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow. Journal of Biomedicine and Biotechnology. DOI: 10.1155/2009/829243. 
42. Miyoshi H,* Matsuo Y, Liu Y*, Sakata T, Mori H. (2009) Behaviors of the fluorescent molecules bound to the interior of the silica nanocapsules in various solvents. Journal of Colloid and Interface Science. 331: 507-513. 
43. Yang H, Li K, Liu Y*, Liu Z, Miyoshi H. (2009) Poly(D,L-lactide-co-glycolide) nanoparticles encapsulated fluorescent isothiocyanate and paclitaxol: preparation, release kinetics and anticancer effect. Journal of Nanoscience and Nanotechnology. 9: 282-287. 
44. Liu Y*, Miyoshi H. (2008) Preparation and characterization of novel drug delivery system of light-sensitive silica nanocapsules with thin shells. Journal of Biomedical Nanotechnology. 4: 25-32. 
45. Guo Z, Cai SX, Fang R, Chen H, Du J, Tan Y, Ma W, Hu H, Cai SH, Liu Y*. (2007) The synergistic effects of CXCR4 and EGFR on promoting EGF-mediated metastasis in ovarian cancer cells. Colloids and Surfaces B: Biointerfaces. 60: 1-6. 
46. Liu Y*, Miyoshi H, Nakamura M. (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles. International Journal of Cancer. 120: 2527-2537. 
47. Liu Y*, Miyoshi H, Nakamura M. (2007) Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics. Colloids and Surfaces B: Biointerfaces. 58: 180-187. 
48. Liu Y*, Miyoshi H, Nakamura M. (2006) Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. Journal of Controlled Release. 114: 89-99. 
49. Liu Y* Yang H, Su Q, Sakanishi A. (2006) Influence of parenteral fat emulsion Intralipos and citric acid on blood viscosity and erythrocyte morphology in vitro. Colloids and Surfaces B: Biointerfaces. 53: 51-54. 
50. Liu Y*, Yang H, Takatsuki H, Sakanishi A. (2006) Effect of ultrasonic exposure on Ca2+-ATPase activity in plasma membrane from Aloe arborescens callus cells. Ultrasonics Sonochemistry. 13: 232-236. 
51. Liu Y*, Yang H, Sakanishi A. (2006) Ultrasound: mechanical gene transfer into plant cells by sonoporation. Biotechnology Advances. 24: 1-16. 
52. Liu Y, Uno H, Takatsuki H, Hirano M, Sakanishi A. (2005) Interrelation between HeLa-S3 cell transfection and hemolysis in red blood cell suspension using pulsed ultrasound of various duty cycles. European Biophysics Journal with Biophysics Letters. 34:163-169. 
53. Liu Y*, Yang H, Otaka K, Takatsuki H, Sakanishi A. (2005) Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate on human monocytic THP-1 cell migration. Colloids and Surfaces B: Biointerfaces. 43: 216-220.
本科生:分子生物學(雙語教學)
研究生:生物力學與組織工程學
地  址:四川省成都市建設北路2段4號
            電子科技大學 生命科學與技術學院
電  話:028-83203353(辦);028-83208238(傳真)
E-mail:  liuyiyao@uestc.edu.cn  
歡迎訪問實驗室網站:http://biophysics.uestc.edu.cn
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